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Brand

Droncit

Availability

23 mg and 34 mg tablets, 56.8 mg/mL injectable in 10mL vial

Pharmacology:

A synthetic, heterocyclic anthelmintic agent, that is a derivative of pyrazinoisoquinoline.

It has broad-spectrum action against cestodes that stimulate the worm’s motility, and impairs the sucker function which allows for passive dislodgement. The drug, also, has a direct kill effect on schistosomes and trematodes.

Praziquantel is rapidly absorbed after oral administration. It is distributed throughout the body crossing the blood brain barrier into the central nervous system and across the intestinal wall. It is metabolized in the liver and excreted in urine.

Indications:

Used for treatment of tapeworms, flukes, schistosomes and trematodes.

Drug Interactions or Contraindications:

Possible antagonism with Piperazine salts.

Adverse Reactions:

CNS:  lethargy

GI:   diarrhea, anorexia

Skin:  itching

Dosage Recommendations

5 mg/lb SQ once and repeat in 10 days ^{4  3}

or

6 mg to 10 mg PO ¹

or

30 mg/kg q14 days x 3 treatments; PO ¹

Considerations

When giving PO give with food as tablets are bitter.

Posted on June 23, 2003, 15:59, Last updated on June 10, 2008, 18:58 | Anti-Infectives