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Aminoglycosides are a group of drugs that share chemical, antimicrobial, and pharmacological characteristics,as well as mechanism of action, metabolism and toxicity.

They do, however; differ in their clinical use. Refer to the Rat Medication Guide Index for individual drugs listed under Aminoglycosides.

This group of drugs are bactericidal against Gram-positive and Gram-negative organisms as well as mycoplasma.

They are generally poorly absorbed after oral administration but do well when given parenterally. They cross the placental barrier and are moderately well distributed except for the central nervous system.

Aminoglycosides have dose related toxic effects as well as being both ototoxic and nephrotoxic. Nephrotoxicity will vary in degree according to the particular drug that is used.

Finally, caution should be used in those having renal insufficiency since excretion is primarily through glomerular filtration.

Posted on June 17, 2003, 15:24, Last updated on September 30, 2008, 19:25 | Antimicrobial Agents