Back to Cardiovascular Drugs
Effects from atenolol’s negative inotropic and chronotropic action are a decrease in the sinus heart rate, slowed AV conduction, a decrease in cardiac output, decreased myocardial oxygen demand and decreased blood pressure.
The drug is rapidly absorbed and distributed to most tissues. It crosses the placental barrier and is seen in cord blood. Fertility of male or female rats (evaluated at dose levels as high as 200 mg/kg/day or 100 times the maximum recommended human dose)however, were shown to be unaffected by the administration of atenolol.
Atenolol is biotransformed in the liver, and excreted in both milk and urine.
Quinidine, diltiazem, verapamil will increase effects of atenolol.
Increased toxicity is seen when used with lidocaine, insulins, and prazosin.
Additive myocardial depression may occur when used concurrently with anesthetic agents.
Furosemide and hydralazine when used with atenolol enhances the hypotensive effect.
CV: hypotension, bradycardia
0.2 mg/kg to 2 mg/kg, PO, q24hrs 34
Posted on June 23, 2003, 16:04,
Last updated on May 27, 2012, 16:32
| Cardiovascular Drugs