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It reduces vasoconstriction causing a decrease in peripheral resistance, a decrease in pulmonary vascular resistance, and right atrial pressure in the heart. It increases cardiac ouput, and stroke volume. It has the ability to decrease heart rate and increase renal blood flow.
Enalapril is absorbed orally and Enalaprilat by injection or IV. They are both poorly distributed into the central nervous system, but do cross the placental barrier. Both forms are excreted in urine and feces.
Use of NSAIDs with enalapril may reduce its efficacy.
Use with caution where azotemia is present.
CNS: sleep disturbances
GI: diarrhea
Renal: May cause transient increase in BUN and creatinine levels
Blood: neutropenia, agranulocytosis
Skin: itching
Posted on June 23, 2003, 16:03,
Last updated on June 10, 2008, 17:22
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