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Enalapril/enalaprilat reduces vasoconstriction causing a decrease in peripheral resistance, a decrease in pulmonary vascular resistance and right atrial pressure in the heart. It increases cardiac output, and stroke volume. It has the ability to decrease heart rate. It also has the ability to increase renal blood flow, which may help to preserve renal function by decreasing proteinuria in animals with glomerular disease (Plumb, 2008).
Enalapril is absorbed orally and enalaprilat by injection or IV. They are both poorly distributed into the central nervous system, but do cross the placental barrier. Both forms are excreted in urine and feces.
Use of NSAIDs with enalapril may reduce its efficacy.
Use with caution where azotemia is present.
Potential for increased hypotensive effects when used in conjunction with diuretics (e.g.Lasix) or other vasodilators (see Considerations).
CNS: sleep disturbances
Renal: May cause transient increase in BUN and creatinine levels
Blood: neutropenia, agranulocytosis
Initial dose 0.5 mg/kg, PO, BID (may be titrated up based on veterinary discretion to the rat’s response) 12
Note: a once a day dosing may be divided and given twice a day as determined by veterinarian assessment of condition.
Posted on June 23, 2003, 16:03,
Last updated on January 11, 2017, 14:37
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