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DMSO appears to have anti-inflammatory and analgesic properties, as well as some antibacterial and antifungal activity.
DMSO is able to penetrate skin easily, and is well absorbed following topical application. It is widely distributed to all areas of the body. DMSO metabolizes to dimethyl sulfide, and is excreted primarily by the kidneys.
Some studies indicate that DMSO is carcinogenic at high doses over lifetime in rats.
Studies also indicate that DMSO is not teratogenic in rats or mice.6 However, risk versus benefit should be taken into consideration if planning to use this preparation in rats or mice that may be pregnant or nursing.
DMSO is classified as a nutritional supplement. The classification is defined by the U.S. Dietary Supplement Health and Education Act, Oct. 25, 1994, and states that to be a nutritional supplement it should contain one or more of the following dietary ingredients: a vitamin, mineral, amino acid, herb or other botanical; and that it be intended for ingestion in the form of a pill, capsule, tablet, gel-cap or liquid form. Also that it not be represented as a conventional food or as a sole item of a meal or the diet, and that it is labeled as a dietary supplement.
DMSO will degranulate mast cells, caution is advised if using in conditions where mastocytoma is suspected or has been diagnosed.
DMSO can have an effect on vasodilation and diuresis. Refrain from use in rats that are dehydrated or appear to be in shock.
DMSO may potentiate the effects of atropine, corticosteroids or insulin.
Avoid use in conjunction with organophospates or cholinesterase inhibitors, due to DMSO’s anticholinesterase activity.
Other: heptotoxicity, renal toxicity
Posted on February 21, 2004, 10:23,
Last updated on January 1, 2009, 20:31
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