Back to NSAIDs
It is interesting to note that some forms of cancer such as carcinomas (e.g. Squamous Cell Carcinoma and mammary adenocarcinoma) appear to exhibit COX-2 activity. Studies suggest that these types of NSAIDs may have anti-tumor effects, besides their anti-inflammatory effects. This may make them useful in palliative care where tumors are inoperable.
Piroxicam is rapidly and well absorbed by the gut, and is distributed into synovial fluid as well as plasma. It has an extensive serum half-life greater than that of meloxicam. Piroxicam goes through biotransformation in the liver and excretes metabolites in urine. It has not been found to have teratogenic effects in animals, and has only exhibited minimal concentration in breast milk.
Can inhibit platelet aggregation and cause GI erosion, avoid concomitant use if giving aspirin, phenylbutazone, corticosteroids or other NSAIDs.
Not recommended if gastrointestinal irritation and hemorrhage, or impaired hepatic, cardiac, or renal function present.
Caution when using with aminoglycosides (e.g.,gentamicin, amikacin); may increase risk of nephrotoxicity.
Can decrease the antihypertensive effect of ACE inhibitors.
May reduce the diuretic effect of furosemide (Lasix).
Can increase serum levels of digoxin.
GI: loss of appetite, GI ulceration, fecal occult blood
GU: renal papillary necrosis
Hematologic: anemia, may falsely elevate blood glucose levels
Hepatic: elevated liver enzymes
Skin: pruritus (itching)
Other: peripheral edema
Due to the extensive half-life of piroxicam and potential for GI ulceration, when choosing to use for long term treatment in specific disorders, lower dose adjustments and extended frequency of dosing to every other day should be a consideration of the veterinarian.
0.1 mg/kg to 0.3 mg/kg, PO, every other day (maintenance, long term use) 12
*Note: because of the potential for GI ulceration with long term use of piroxicam it is recommended that an anti-ulcer agent (e.g.sucralfate) be used concurrently.
Posted on June 23, 2003, 16:26,
Last updated on May 31, 2013, 16:49