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Tobramycin Ophthalmic

Ophthalmics
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Brand

Tobrex

Availability

Ophthalmic solution: 0.3%
Ophthalmic ointment: 0.3%

Pharmacology

Tobramycin, an aminoglycoside, is a bactericidal agent that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.

Its spectrum of activity includes aerobic Gram-negative organisms and some aerobic Gram-positive organisms.

Tobramycin ophthalmic is an FDA pregnancy category B drug, and thought to be safe for use during pregnancy. However, it is unknown whether tobramycin ophthalmic is passed in breast milk. Check with veterinarian prior to use in pregnant or lactating rats.

Indications

Used for the treatment of external eye infection where Gram-negative bacteria are thought to be the cause.

Drug Interactions or Contraindications

Not recommended for long-term use due to possible overgrowth of non-susceptible organisms.

Do not use in infections where viral or fungal organisms are believed to be the cause.

Adverse Reactions

CNS:  temperature elevation

EENT: blurred vision, burning or stinging on instillation, lid itching or swelling, conjunctival redness.

Other:  overgrowth of non-susceptible organisms.

Dosage Recommendations

Apply one drop to affected eye 4 to 5 times per day, or as directed by the vet. 12

Considerations

  • Pet owners should be sure to wash hands before and after applying drops or ointment to a rat’s eye(s). Wipe excessive lacrimation (porphyrin around the eyes in rats) or debris from eye(s) before application. Do not touch dropper or tube opening to any surface, including eyes or hands. The dropper or tube opening is sterile, and if contaminated it could cause additional infection in the eye.
  • Do not use any eyedrop that is discolored or has particles in it. Check expiration date.
  • Discontinue use if the following occurs: keratitis, redness, increased lacrimation, swelling of eye, or if rat starts to scratch eye in attempt to relieve itching.
  • Store tobramycin ophthalmic at room temperature away from moisture and heat. Keep the bottle or tube properly capped.

Posted on February 15, 2007, 20:21, Last updated on May 31, 2010, 11:39 | Ophthalmics



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