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Chlorpheniramine Maleate

Respiratory Drugs
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Chlor-Trimeton, Aller-Chlor


Tablets: 4 mg
Syrup: 2 mg/5mL


An alkylamine derivative, this drug is among the most potent of antihistamines but unlike the ethanolamine derivatives is only minimally sedative. Like other antihistaminics it blocks histamine at the receptor site.

It is well absorbed orally and distributed in high levels to spleen, lungs, and brain. It is able to cross the placental barrier.

The drug is metabolized in the liver and excreted as metabolites in urine and breast milk.


Used where allergy symptoms, or nasal congestion, are present.

Drug Interactions or Contraindications:

Use cautiously with central nervous system depressants as it can increase sedative effect.

Do not use for acute asthmatic attacks.

Do not give to lactating rats.

Adverse Reactions

CNS:  drowsy, poor coordination, tonic/clonic seizures

CV:  palpitations

GI:  dry mouth, diarrhea, constipation

GU:  urine retention

Other: may cause thick bronchial secretions

Dosage Recommendations

*Rat approved dosages still being determined. Dosage below is empirical.*

0.2 mg/lb, PO, BID, for allergy/respiratory symptoms  3


  • Can be purchased over the counter.
  • Give lots of fluids to decrease bronchial secretion viscosity.
  • Avoid milk products.
  • Give with food to avoid GI reactions.
  • Store drug at room temperature.

Posted on June 23, 2003, 16:42, Last updated on August 31, 2013, 21:11 | Respiratory Drugs

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