Extensive histopathology showed chronic granulocytic leukemia which is the type of leukemia that originates in the bone marrow (myelogenous leukemia). This is a very rare leukemia in rats.
Even though most of his organs were infiltrated by malignant granulocytes it is theorized that the chronic nature of his disease enabled the organs to slowly compensate.
In the above photo it is apparent that Zissou had a disease that caused severe physical wasting.
In the above left necropsy photograph it is apparent that the liver is greatly enlarged (hepatomegaly) as well as the spleen (splenamegaly). You can see the yellow/brown discoloration of these organs which is usually indicative of either a severe systemic infection or cancer infiltration.
The right photo shows the enlarged kidneys (renamegaly) as well as some affected lymph nodes. The kidneys are typically dark red and about half the size of these. The lymph nodes (lumbar and renal) are usually not visible.
Once again we see the discoloration that we noticed in the other organs.
Posted on January 11, 2010, 14:41,
Last updated on April 28, 2014, 13:20