We consulted our vet after the first seizure.
So frantic was Motely that we had to place him in an isolation box so he wouldn’t hurt himself or his cagemates. We had sedative injectable on hand to give him when this happened, if needed.
We suspected there was a brain chemistry-hormonal issue, as his seizures started at adolescence and always occurred with hyper-dominance / aggressive behaviour. He was given a chemical castration drug called Tardak (generic name delmadinone by Pfizer), dose based on 0.1 mL / 500 gm rat repeated in 10 days, to lower his hormones, as a test.
[Note: we are not sure whether he was helped by the reduced hormones or the side effects of Tardak - as it has a calming side effect which has been used to control some seizures in dogs]
Later as the effects of the Tardak were reduced, we opted to try a behavioral modification drug called Clomicalm1, to reduce the agitation which seemed to occur before the seizures. Mote was initially given 0.5mg twice daily, and then tried at a higher dose a few weeks later at 1mg twice daily. Dosing for Mote was based on a weight of about 450-475g. The dose for Mote was provided from the 5 mg tablets of Clomicalm1, which was crushed up and added to food.
This seemed to help a some.
Of note, Mote was never a very large rat. Downunders were quite small rats to start with. Mote was always quite a fidgety rat, always bustling about and wired like he was on caffeine.
The following are Motely’s weights at specific ages.
At 9 months when seizures started - 440g.
Maximum weight at 13 months - 510g.
At 18 months when he died - 475g.
While the following photos do not show active seizures, they have been included to show Motely’s size, type, and markings.
Photo 1: Shows Motely’s downunder markings.
Photo 2: Shows more of Motely’s markings.
Photo courtesy of Al and Robyn Arthur, of The Dapper Rat, http://www.dapper.com.au
Collaborated case history by, Dr Larissa Ladyko B.V.Sc, and Robyn Arthur.
Posted on January 17, 2005, 17:42,
Last updated on April 9, 2010, 16:57