Zymbal’s gland carcinoma
Carcinoma of the Zymbal’s gland characterized by circumscribed mass of irregular acini or solid sheets of cells containing cystic cavities filled with sebum, keratin and necrotic cells; neoplastic sebaceous and squamous cells are often pleomorphic and anaplastic; multifocal areas of papillary projections of squamous epithelium in cystic spaces; multifocal areas of branching cords of cells showing squamous differentiation; multifocal areas of acini consisting of solid sheets of fusiform cells with elongated nuclei and scant cytoplasm; focal regions consisting of predominantly anaplastic spindle cells with small foci of neoplastic squamous epithelium; multiple regions showing transition from neoplastic squamous epithelium to anaplastic, pleomorphic cells with occasional mitotic figure; multifocal regions of inflammatory eosinophils and lymphocytes in the well formed stromal cells.
Progression of cancerous mass involving Zymbal’s gland.
Histopathology: by IDEXX RADIL
Necropsy, and photos: Joanne “Bella” Hodges
Posted on April 8, 2010, 13:09,
Last updated on February 3, 2011, 13:11