Medications and Breeding

Safe in pregnancy:

  • Azithromycin
  • Tylosin
  • Amoxicillin
  • Amoxicillin with clavulanate
  • Cefadroxil
  • Prednisolone


  • Most Fluoroquinolones: Ciprofloxacin/Enrofloxacin (Baytril) *
  • Flagyl
  • Reglan
  • Albuterol
  • Trimethoprim/sulfa
  • Aspirin (Can cause birth defects in rats)
  • Tetracyclines (May impede development of fetal bones and teeth)

Medications That Decrease Fertility in Males:

  • Diazepam
  • Chlorpromazine
  • Estrogens

* The Fluorquinolone studies for toxicity were done using toxic levels of the drug (LD50 or above) rather than the therapeutic level, which may indicate that these medications may be used if the benefit is greater than the risk.

If you choose to use these fluoroquinolones check with a vet and do not dose babies if mom is being dosed (as the babies will receive it in the maternal milk.)


For more information on the drugs listed above see individual monographs located in the Rat Medication Guide.


The Rat Guide and its affiliates accept no responsibility for misuse or misunderstanding of its information. This guide in whole or part, exists solely for the purpose of recognizing and understanding the care and illnesses in the pet rat. Please seek advice and treatment from a qualified Veterinarian if your rat is ill.

2000 - 2024 by Karen Grant RN. All rights reserved.
All other written and visual materials used by permission of specific authors for the sole use of the Rat Guide. Please visit our Privacy Policy for details.
Brought to you by KuddlyKorner4u
See Logos page for linking to the Rat Guide.
Contact us here: Rat Guide Team
Please note: Rat Guide email is not checked daily. Send e-mail to if you have an urgent medical problem with your pet rat. When possible, it is always best to take your rat to a qualified rat veterinarian.