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Chloromycetin Sodium Sumlinate (powder for injection)
Capsules: 250 mg Chloromycetin Kapseals
Injectable: 1 gram vial (100 mg/mL) Chloromycetin Sodium Sumlinate
Chlormaphenicol is rapidly absorbed following oral administration and widely distributed throughout the body, including the central nervous system, where it is able to cross the blood-brain barrier. While highest levels are found in the liver and kidney the drug tends to remain at therapeutic levels in most tissues and fluids 27.
Chloramphenicol is metabolized in the liver and eliminated by glucuronidation. It is excreted by the kidneys with only a small fraction being excreted unchanged.
Though chloramphenicol is quite effective at getting into the tissues, being able to penetrate pus to get to the bacteria, it has a short half-life which requires more frequent dosing times.
It also has the potential to accumulate at toxic levels in the newborn, and very young, due to the inability to be effectively metabolized and eliminated from the body. It is, therefore, not recommended to be given to very young animals.
Chloramphenicol is also not recommended to be given in pregnant or lactating animals due to its ability to cross the placenta and passed in breast milk.
Not recommended for use with Tylan, azithromycin or erythromycin, as they may be antagonistic with chloramphenicol.
Acetaminophen will elevate chloramphenicol levels.
Chloramphenicol has the potential to antagonize bactericidal activity of the penicillins and aminoglycosides.
Rifampin may decrease serum chloramphenicol levels.
EENT: optic neuritis
GI: diarrhea, disturbance of intestinal flora
Hematologic: irreversible idiosyncratic aplastic anemia (identified in humans), dose-related bone marrow suppression with long term therapy (reversible once drug stopped)
May falsely elevate urine glucose levels.
(Chloramphenicol sodium sumlinate) 15 mg/lb to 25 mg/lb , SQ or IM, BID for 7-14 days 4
Posted on June 23, 2003, 14:30,
Last updated on April 6, 2010, 15:37
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