Paracetamol (as known in the U.K.)
Brand
Tylenol Tablets, Children’s Tylenol Suspension , Infant’s Tylenol Concentrated Drops.
Pharmacology
A phenol derivative, it is both analgesic and antipyretic. It inhibits the synthesis of prostaglandins that sensitize pain receptors to stimulation. Unlike aspirin it is not an antiinflammatory agent.
This drug is both rapidly and completely absorbed and is widely distributed into the tissues.
Indications
Used to relieve minor pain
Drug Interactions or Contraindications
Not recommended to be used post-op in animals having received Halothane.
Concurrent use with loop diuretics such as furosemide may increase the risk of ototoxicity.
Do not use in renal or hepatic diseases
Adverse Reactions
Skin: itching
GU: analgesic nephrotoxicity
Hepatic: long term use or single high dose can lead to toxicity resulting in renal insufficiency and liver failure.
Renal: studies in rats have shown tubular necrosis with high dosages.
Dosage Recommendations
Recommended method :Children’s Tylenol= 1 mg/mL to 2 mg/mL in drinking water (based on 100mL of drinking water).
1
or
90 mg/lb to 140 mg/lb ; PO (oral) , q4hrs 3
or
100 mg/kg to 300 mg/kg; PO (oral), q4hrs 19
Considerations
For short term use only. If used repeatedly, use a decreased dosage.
ALERT: Always verify drug concentrations when calculating dose. If using the following remember: Infants’ Tylenol Concentrated Drops has a higher concentration of drug permL than does Children’s Strength Tylenol Suspension.
Store drug at room temperature.
Posted on June 16, 2003, 10:19,
Last updated on March 17, 2008, 17:12
| Analgesics
