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As Amitraz 19.9% topical solution for dilution in 10.6 mL bottles.


Amitraz is a diamide topical antiparasitic agent belonging to the class of monoamine oxidase inhibitors. It appears to effect the central nervous system of those organisms that are susceptible. It also appears to have alpha-2 adrenergic ability.

This drug can cause significant increase in plasma glucose levels by inhibiting insulin release via alpha-2 adrenergic activity.

The safety of this drug has not been established in young animals or pregnant animals.


Used in treatment for demodectic mange, notoedres, and sarcoptid mites.

Drug Interactions or Contraindications

Do not mix with other antiparasiticides.

Do not use corticosteroids and other immunosuppressants in animals with demodicosis due to immunosuppressive effects.

Ivermectin recommended safer to use in pet rats.

Adverse Reactions

CNS:  transient sedation

GI:  may be toxic if swallowed

Dosage Recommendations

An established dose for use in rats is to dilute 5X the recommended amount for dogs and apply with a cotton bud (Q-tip or swab) to, or wash, animal at 2 week intervals for 3 to 6 treatments (ie; 10.6 mL or 1 bottle in 10 gal. water). This method safer for rodents since surface to body ratio is greater than dogs. Following the treatment keep the rat warm and free from drafts until dry. (1)


  • If treating around eyes, use ophthalmic protectant with petrolatum before treating.
  • Refrain from use in pyoderma until lesions healed.
  • Amitraz is flammable until diluted in water. Wear gloves while treating animal, protect any exposed skin on hands and arms and wash thoroughly after treatment. Avoid any vapors and flush unused portion down drain, and rinse any container used to mix with water and then dispose.
  1. Tynes, V. (1998). Drug therapy in pet rodents. Vet Med, 93(11), 988-991. Abstract retrieved August 31, 2013, from http://www.vspn.org/vspnsearch/aow/drugtherapyinpetrodents.htm

Posted on June 28, 2003, 07:01, Last updated on September 2, 2013, 15:53 | Anti-Infectives

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