Abbreviation
FBZ
Brands
Panacur Granules, Panacur Suspension (OTC), Panacur Paste (OTC), Safe-Guard Suspension (OTC), Safe-Guard Paste (OTC)
Pharmacology
Fenbendazole is a benzimidazole anthelmintic, that has broad-spectrum, and a wide safety margin.
It binds to 3-tubulin astructural protein that blocks polymerization of tubulin into microtubules, which damages the integrity and the transport function of cells in parasites.
The reason behind the wide safety margin is due to its infinity to the parasitic tubules rather than mammalian.
It is considered safe for use in pregnancy in all species.
The drug is minimally absorbed after it is given orally. It is metabolized to the active compound oxfendazole sulfoxide and sulfone.
Fenbendazole is excreted in the feces and urine.
Indications
For use in the removal of ascarids, hookworms, Taenia species of tapeworm, pinworms, and roundworms. Also effective against giardia, a protozoan.
Drug Interactions or Contraindications
Fenbendazole is not recommended to be given concurrently with bromsalan flukicides due to the possibility that it can cause abortions in animals.
Adverse Reactions
May cause hypersensitivity.
Dosage Recommendations
23 mg/lb once a day for 3 days
3
or
20 mg/kg , PO, q24hrs for 5 days 2
Considerations
- Store at room temperature.
Posted on June 23, 2003, 15:56,
Last updated on May 31, 2010, 20:27
| Anti-Infectives
