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Fenbendazole

Anti-Infectives
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Abbreviation

FBZ

Brands

Panacur Granules, Panacur Suspension (OTC), Panacur Paste (OTC), Safe-Guard Suspension (OTC), Safe-Guard Paste (OTC)

Pharmacology

Fenbendazole is a benzimidazole anthelmintic, that has broad-spectrum, and a wide safety margin. It binds to 3-tubulin astructural protein that blocks polymerization of tubulin into microtubules, which damages the integrity and the transport function of cells in parasites. The reason behind the wide safety margin is due to its infinity to the parasitic tubules rather than mammalian. It is considered safe for use in pregnancy in all species.

Fenbendazole is minimally absorbed after it is given orally, and is metabolized to the active compound oxfendazole sulfoxide and sulfone. It is excreted in the feces and urine.

Indications

For use in the removal of ascarids, hookworms, Taenia species of tapeworm, pinworms, and roundworms. Also effective against giardia, a protozoan.

Drug Interactions or Contraindications

Fenbendazole is not recommended to be given concurrently with bromsalan flukicides due to the possibility that it can cause abortions in animals.

Adverse Reactions

May cause hypersensitivity.

Dosage Recommendations

20 mg/kg, PO, q24hrs for 5 days   2

Considerations

  • Store at room temperature.

Posted on June 23, 2003, 15:56, Last updated on August 24, 2014, 21:12 | Anti-Infectives



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