Fenbendazole

(abbreviation: FBZ)

Brands

Panacur Granules, Panacur Suspension (OTC), Safe-Guard Suspension (OTC)

Availability

  • Suspension: 10% (100 mg/mL)
  • Granules: 22.2% (222 mg/gm)

Pharmacology

Fenbendazole is a benzimidazole anthelmintic, that has broad-spectrum, and a wide safety margin. It binds to 3-tubulin astructural protein that blocks polymerization of tubulin into microtubules, which damages the integrity and the transport function of cells in parasites. The reason behind the wide safety margin is due to its infinity to the parasitic tubules rather than mammalian.

It is considered safe for use in pregnancy in all species.

Fenbendazole is minimally absorbed after it is given orally, and is metabolized to the active compound oxfendazole sulfoxide and sulfone. It is excreted in the feces and urine.

Indications

For use in the removal of ascarids, hookworms, Taenia species of tapeworm, pinworms, and roundworms. Also effective against giardia, a protozoan.

Drug Interactions or Contraindications

  • Fenbendazole is not recommended to be given concurrently with bromsalan flukicides due to the possibility that it can cause abortions in animals.
  • Do not use fenbendazole on sick or malnutritioned rats, or on rats that are under 5 weeks old.

Adverse Reactions

May cause hypersensitivity, although none significantly reported.

Dosage Recommendations

10 mg/kg, PO, once, when treating for pinworms. 27

or

20 mg/kg, PO, q24hr for 5 days.  2, 41

or

20 mg/kg to 50 mg/kg, PO, q24hr for 5 consecutive days. *Note: higher dosing end for giardiasis only!*  27, 42

Considerations

  • Store suspension as directed on label.
  • Store granules in a tightly sealed container at room temperature. Protect from sunlight.

Cross-references

Links to

Linked from

Disclaimer

The Rat Guide and its affiliates accept no responsibility for misuse or misunderstanding of its information. This guide in whole or part, exists solely for the purpose of recognizing and understanding the care and illnesses in the pet rat. Please seek advice and treatment from a qualified Veterinarian if your rat is ill.

2000 - 2020 by Karen Grant RN. All rights reserved.
All other written and visual materials used by permission of specific authors for the sole use of the Rat Guide. Please visit our Privacy Policy for details.
Brought to you by KuddlyKorner4u
See Logos page for linking to the Rat Guide.
Contact us here: Rat Guide Team