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Aminoglycosides do not readily cross the blood-brain barrier. However, they are able to cross placental barrier, and may cause nerve or nephrotoxic effects to the fetus. It is not recommended that these drugs be used in pregnant rats.
Amikacin has the same spectrum of activity as gentamicin and tobramycin, but it is less susceptible to enzymatic inactivation. This makes amikacin valuable in managing infections caused by Gram-negative bacilli resistant to gentamicin and tobramycin.
Amikacin’s use can include coverage against some aerobic Gram-positive bacteria,which include E.coli, klebsiella, proteus, pseudomonas, salmonella, enterobacter, serratia and mycoplasma.
The drug is almost exclusively eliminated by way of glomerular filtration when given in parenteral form.
Per the manufacturer it is not a recommendation to mix amikacin in with other drug compounds. Give separately.
For other interactions and contraindications check with a pharmacist.
CNS: lethargy,neuromuscular blockade,facial edema, pain/inflammation at injection site.
EENT: ototoxicity (loss of hearing)
GU: nephrotoxicity (oliguria,proteinuria)
or
10 mg/kg to 20 mg/kg per day 11
or
5 mg/lb , SQ or IM , BID or TID, for 7 to 14 days(as recommended on RMCA Drug Chart)
or
2 mg/kg to 5 mg/kg , SQ or IM , q8hrs to q12hrs 1
Posted on June 17, 2003, 15:34,
Last updated on December 12, 2008, 14:24
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