Brand
Cefa Tabs, Cefa-Drops
Availability
For veterinary use: Cefa-Drops 50mg/mL . Comes in powder form 50ml bottle.When mixed with water has an orange flavor taste.
Pharmacology
Cefadroxil is a first generation cephalosporin. It is a broad-spectrum, bactericidal, antibiotic.
The drug is well absorbed orally, and widely distributed throughout the body
crossing both placental and fetal serum. It does not enter cerebral spinal fluid.
It is effective against most Gram-positive organisms. It, however, does not directly attack mycoplasma but is useful in secondary infections.
This drug is excreted in the urine.
Indications
Used for treating skin, soft tissue and urinary tract infections. May be used in combination with gentamicin for respiratory illness where secondary infections are involved. Also good for use prophylatically following surgery to prevent infection.
Drug Interactions or Contraindications
Should not be used orally in cases of septicemia or shock as absorption may be delayed significantly in grave illness.
Use cautiously with aminoglycosides. May have synergistic effect against certain bacteria, when used with the aminoglycosides, penicillins, and chloramphenicol.
Not recommended for concurrent use with bacteriostatics.
Adverse Reactions
Blood: neutopenia, hemolytic anemia
GI: anorexia(poor or no appetite), diarrhea, anal pruritus(itching)
Other: potential for nephrotoxicity minimal in animals.
Dosage Recommendations
10 mg/lb , PO , BID
4 3
Can be given 10 to 30 days
Considerations
Give yogurt, Lactobacillus capsules/granules, or Bene-bac to help maintain normal gut flora.
May store tablets and capsules at room temperature.
Reconstituted suspensions kept refrigerated are good for 14 days.
In treating suspected polymicrobial infections, where a broader coverage may be needed, synergistic or combination drugs may be used. The following drugs may be seen used simultaneously with cefadroxil: aminoglycosides (e.g., amikacin or gentamicin), or clindamycin, or fluoroquinolones (e.g., enrofloxacin or orbifloxicin), or metronidazole, or ampicillin . 1
Please note that it is imperative to discuss the changing or adding of any medications during your rat’s treatment with your veterinarian to prevent future resistance of microbes to the drugs prescribed.
Posted on June 23, 2003, 14:20,
Last updated on June 10, 2008, 19:40
| Antimicrobial Agents
