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Cefadroxil

Antimicrobial Agents
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Brands

Cefa Tabs, Cefa-Drops

Availability

For veterinary use: Cefa-Drops 50 mg/mL . Comes in powder form 50 mL bottle. When mixed with water has an orange flavor taste.

Pharmacology

Cefadroxil is a first generation cephalosporin. It is a broad-spectrum, bactericidal, antibiotic. It is effective against most Gram-positive organisms. It, however, does not directly attack mycoplasma but is useful in secondary infections.

The drug is well absorbed orally, and widely distributed throughout the body crossing both placental and fetal serum. It does not enter cerebral spinal fluid.

This drug is excreted in the urine.

Indications

Used for treating skin, soft tissue and urinary tract infections. May be used in combination with gentamicin for respiratory illness where secondary infections are involved. Also good for use prophylactically following surgery to prevent infection.

Drug Interactions or Contraindications

Should not be used orally in cases of septicemia or shock as absorption may be delayed significantly in grave illness.

Use cautiously with aminoglycosides. May have synergistic effect against certain bacteria, when used with the aminoglycosides, penicillins, and chloramphenicol. Not recommended for concurrent use with bacteriostatics.

Adverse Reactions

Blood:  neutopenia, hemolytic anemia

GI:  anorexia (poor or no appetite), diarrhea, anal pruritus (itching)

Other:  potential for nephrotoxicity minimal in animals.

Dosage Recommendations

10 mg/lb , PO , BID  4
Can be given 10 to 30 days

Considerations

  • Give yogurt, Lactobacillus capsules/granules, or Bene-Bac to help maintain normal gut flora.
  • May store tablets and capsules at room temperature.
  • Reconstituted suspensions kept refrigerated are good for 14 days.
  • In treating suspected polymicrobial infections, where a broader coverage may be needed, synergistic or combination drugs may be used. The following drugs may be seen used simultaneously with cefadroxil: aminoglycosides (e.g., amikacin or gentamicin), or clindamycin, or fluoroquinolones (e.g., enrofloxacin or orbifloxicin), or metronidazole, or ampicillin . 1
  • Please note that it is imperative to discuss the changing or adding of any medications during your rat’s treatment with your veterinarian to prevent future resistance of microbes to the drugs prescribed.

Posted on June 23, 2003, 14:20, Last updated on August 24, 2014, 22:06 | Antimicrobial Agents



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