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When Clavulanate Potassium and Clavulanic Acid, beta-lactamase inhibitors, are used in combined form with the penicillins such as amoxicillin, they prevent hydrolyzed penicillins, like amoxicillin, from being inactivated by bacterial beta-lactamases.
The antibacterial activity of Clavulanate Potassium, and Clavulanic Acid, is weak when used alone and is therefore only available in
combination form. There is no synergistic activity, to speak of, against organisms that are already susceptible to amoxicillin. The combined drug is useful in staphylococcal infections where amoxicillin alone is not.
This combination drug is excreted unchanged in the urine via glomerular filtration.
GI: anorexia,diarrhea
Other: hypersensitivity reaction such as rash and itching.Prolonged high doses can cause neurotoxicity.When given orally the penicillins may alter gut flora,selecting out resistant bacteria residing in the colon(leading to superinfections).
Posted on June 23, 2003, 14:36,
Last updated on August 14, 2008, 18:39
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