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Panmycin, Achromycin-V (Human approved)
As a class the tetracyclines generally act as broad-spectrum bacteriostatic agents inhibiting protein synthesis by reversibly binding to the 30S subunit of bacterial ribosome; thereby blocking access of aminoacyl-tRNA to the acceptor site on the mRNA-ribosome complex preventing the growth of susceptible bacterial organisms. They are also believed to reversibly bind to 50S ribosomes, plus altering the permeability of cytoplasmic membrane in susceptible organisms.(1)
Tetracycline is effective against infections caused by trachoma, rickettsiae, mycoplasma, and chlamydia, as well as, Gram-positive and Gram-negative bacteria.
It is widely distributed to organs and tissues, but only a small amount to central spinal fluid. It is eliminated unchanged primarily via glomerular filtration and may accumulate with repeated dosing in those with impaired renal function. The drug is apparently not metabolized, but excreted into the GI tract where it may become inactive after chelation with fecal material.
See Tetracyclines for additional pharmacological effects.
Has a decreased effect when given with antacids or GI products containing aluminum, calcium, zinc, or magnesium, or with iron containing preparations (example: multivitamins).
Bacteriostatic tetracycline drugs may interfere with the bactericidal effect of the penicillins, cephalosporins, and the aminoglycosides. However, there continues to be discussion regarding whether this interaction is clinically significant.(1)
Increases levels/toxicity of oral digoxin.
Tetracycline Hydrochloride can retard fetal skeletal development, do not use in pregnant animals.
CNS: intracranial hypertension
EENT: sore throat
GI: anorexia (loss of appetite)
Tetracycline hydrochloride: 20 mg/kg , PO, q12h 27
Tetracycline capsules=500 mg of powder mixed in 1 Liter of water 4
*Note: When tetracycline powder from capsules are used in the water bottle, be sure to cover the bottle as the drug is light sensitive. Mixture may be kept in the refrigerator for 3 days, changing the water bottles on the cages daily. Place one ounce per rat in the water bottle daily. Prescription/non-prescription available. Although inexpensive, treating in drinking water is not desired. Remove moist foods from diet while treating with medication in the water to encourage drinking. 4
Posted on June 23, 2003, 14:42,
Last updated on March 13, 2016, 18:58
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