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The pharmacologic effects of atropine are dose related. When given in small doses it inhibits salivary and bronchial secretions. Given in moderate doses atropine can dilate pupils and increase heart rate. At large doses atropine decreases GI motility, and inhibits gastric acid secretion.
Atropine is readily absorbed following oral administration, IM injection, inhalation, or when given via endotracheal administration. It is well distributed in the body crossing into the central nervous system, and across the placenta. It has also been found distributed in breast milk in small quantities.
Atropine is metabolized in the liver and excreted into urine with 30-50% being excreted unchanged.
*In humans atropine is contraindicated where narrow-angle glaucoma is suspected.*
CV: bradycardia (low heart rate) at low doses, tachycardia (high heart rate) at higher doses, arrhythmias (irregular heart rate )
EENT: increased intraocular pressure when used topically in the eye
GI: dry mouth, thirst, constipation
GU: urinary retention
Posted on June 28, 2007, 16:11,
Last updated on May 31, 2010, 19:26
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