Back to Cardiovascular Drugs
It is absorbed in the small intestine, distributed widely in tissues with the highest levels being in kidneys, heart, intestine, stomach, liver and skeletal muscle. The drug is only slightly metabolized, and is excreted by way of glomerular and tubular secretion.
Use cautiously in glomerulonephritis and severe pulmonary disease.
The following drugs may decrease digoxin’s absorption: antacids, cimetidine, metoclopramide, neomycin, and some chemotherapy agents.
Digoxin serum levels may increase or its elimination rate decreased, or toxic effects enhanced with the following drugs: diazepam, quinidine, anticholinergics, sumlinylcholine, verapamil, tetracyclines, erythromycin, furosemide, thiazides, glucocorticoids, and laxatives.
For additional information regarding interactions check with a Pharmacist.
CNS: irritability, lethargy
CV: changes in heart rate, rhythm, irritability of the heart and mechanics of the heart.
GI: decreased appetite, abdominal pain, diarrhea, bowel necrosis.
Smaller dosages should be used in animals with hyponatremia(low sodium), hypokalemia (low potassium), hypercalcemia (high calcium), and hypo or hyperthyroidism.
Posted on June 23, 2003, 16:05,
Last updated on May 31, 2013, 11:28
| Cardiovascular Drugs