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Prednisone and prednisolone have less activity than the longer acting dexamethasone or betamethasone, but exhibit greater activity than hydrocortisone.
Though prednisone and prednisolone are used in the same manner and equally as effective, they should not be confused with each other. Prednisone is activated by the liver into prednisolone. For this reason, and because it is more easily absorbed, prednisolone is the drug of choice when hepatic disease or insufficiency is present.
Both prednisone and prednisolone are readily absorbed and distributed into muscle, liver, intestines, and kidneys. It is also distributed in breast milk and crosses the placental barrier. Glucocorticoids have been found to cause abortion and should not be used in pregnant animals.
They are both metabolized in the liver, and excreted in the urine.
Use with caution in CHF and colitis.
Has only minor mineralcorticoid effect and should not be used alone to treat adrenal insufficiency.
When used with NSAIDs will increase GI distress or cause bleeding, use with caution.
CV: CHF, edema
GI: Known to increase appetite but may have opposite effect in rats with resulting weight loss.
GU: Increased thirst and urination due to activity in the kidney leading to conservation of salt.
Skin: delayed wound healing
Local: atrophy at injection site
Other: may mask or exacerbate infections already present.
if oral solution of 1mg/1 mL then give 0.25mL/lb to 1 mL/lb 4. May be given in divided dose q12hr.
Example of a typical method of administration for prednisone or prednisolone
Divided dose q12h times three days, then once daily times three days, then once every other day as directed by veterinarian.
Examples of reduction/weaning schedules when terminating prednisone or prednisolone administration
Divided dose q12h times three days, then decrease to once daily times three days, then decrease to half that dose and give once a day for three days and then every other day for three doses and stop.
Dosing once a day times two days, then decrease to half of that dose and give once a day times two days, then decrease by half again and give once a day times two days, then decrease by half that again and give once a day times two days and then stop.
The veterinarian may choose a different dosing and reduction schedule based on the rat’s condition.
*Note: Prednisone or Prednisolone is normally used for a few days to a couple of weeks, but where illness is deemed terminal it may be used longer to provide comfort to the rat.
Check with veterinarian prior to stopping, or to determine how best to gradually reduce dosage.
Posted on June 23, 2003, 16:14,
Last updated on September 26, 2014, 16:47
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