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*Note: OTC HUMAN PRODUCT EQUIVALENT TO THE VET FORMULA: TRIPLE ANTIBIOTIC OPHTHALMIC OINTMENT.
Human product: Neosporin Ophthalmic Solution uses gramicidin in place of bacitracin. They are virtually the same except that gramicidin is more soluble in water when using in a solution.
Bacitracin zinc, rarely used systemically due to its nephrotoxic effects, but when used as an ophthalmic preparation does not penetrate the cornea in therapeutic amounts and causes no systemic effect. It is also nonirritating to the eye.
It is useful in the treatment of superficial infections caused by Gram-positive bacteria. A broader spectrum of antimicrobial activity occurs when combined with neomycin and polymyxin B in ophthalmic ointment.
Neomycin sulfate contained in the combination eye ointment has a broad antibacterial spectrum and a low index of allergenicity. It is an active topical sensitizer and can cause cross-sensitivity reactions to systemically used antibiotics that are chemically related to neomycin. It is effective when used in combination with bacitracin and polymyxin for treating superficial ocular infections involving the conjunctiva and cornea.
Polymyxin B sulfate has activity against Gram-negative bacteria. Hypersensitivity reactions to the topical Polymyxin are practically unheard of. An intact corneal epithelium prevents penetration into the eye, but in the presence of epithelial damage from abrasion or ulceration penetration is effective.
The combination of these three antibiotics provides a more effective bactericidal action against Gram-positive and Gram-negative bacteria infections of the eyes.
Do not use in infections where viral or fungal organisms are believed to be the cause.
Other: overgrowth of non-susceptible organisms.
Apply thin film 4 times daily, and up to every 30 minutes in established corneal infections (under direction of a veterinarian). 27
Instillation of a triple antibiotic ophthalmic solution as directed by veterinarian.
Posted on April 18, 2010, 13:02,
Last updated on May 23, 2010, 10:52