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Guaifenesin (OTC)

Respiratory Drugs
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Benylin-E, Humibid, Organidin NR, Robitussin.
Children’s Mucinex (labeled chest congestion in grape flavored).


Capsules: 200 mg
Tablets: 100 mg
Syrup: 100 mg/5 mL


Guaifenesin increases respiratory tract fluid by reducing adhesiveness and surface tension. This in turn helps to thin the mucus making it easier to cough up and remove from the airways.

Guaifenesin is conjugated in the liver and excreted into the urine. It is reported to cross placental barrier; however adverse effects in newborns have not been documented at this time.


Used for relief in bronchitis and respiratory infections where a dry, non productive, cough is present.

Drug Interactions or Contraindications

Contraindicated in hypersensitivity.

Not recommended in coughs accompanied by excessive secretions.

Adverse Reactions

CNS: drowsiness, restlessness.

GI: poor appetite.

Dosage Recommendations

1/10th the child’s dose ( dosage in rats is empirical ) 3


  • Encouraging fluids, and fruit that is juicy, along with the use of a humidifier help to liquify secretions.
  • Store at room temperature.

Posted on June 28, 2003, 07:21, Last updated on November 19, 2012, 13:43 | Respiratory Drugs

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