Back to Anti-Infectives
Zimecterin, Rotectin 1, Equalvan, Equimectrin, Bimectin (Horse wormer paste containing 1.87% ivermectin: See Dosage Recommendations section)
See Dosage Recommendations section for the following:
Ivermectin Oral Sheep Drench: 0.08% = 0.8mg/mL solution (USA)
Brand name: Ivomec Drench for Sheep
Ivermectin Sheep Drench Oral: 0.8 g/L = 0.8mg/mL solution (Australia)
Brand name: Ausmectin Sheep Drench
*Note: when using ivermectin to rid mites it does not kill mites eggs but rather the hatchlings when used repeatedly at the appropriate intervals and dosage.
Ivermectin is well absorbed orally, parenterally, and as pour-on formulas. Efficacy is greatest in oral, and in SQ treatment.
Concentration of the drug remains in the body fluids for extended periods with the highest concentration being in the liver and fat tissues. The drug does not easily penetrate cerebral spinal fluid which minimizes toxicity. It is metabolized in the liver and mostly excreted in feces with a lesser amount excreted in urine.
Studies report that ivermectin given to rats during pregnancy showed a 3x higher concentration in maternal milk than maternal plasma first day postpartum that resulted in increased death in perinatal pups. Dosage given in study was 0.2 mg/kg/day.
Reports also indicate that ivermectin is teratogenic in rats, as well as rabbits and mice, at human materno-toxic dose levels. Abnormalities reported are limited to cleft palate. Dosage used in this study was 0.2 mg/kg/day (MSD, 1988. See references below).
There is no reported documentation of studies done at therapeutic doses for rats at this time.
*Note: based on above information it is not recommended that ivermectin be given to pregnant rats, or Does nursing baby rats under 2 weeks of age.
CNS: lethargy, “drunken gait”, tremors, seizures
Horsewormer paste containing 1.87 % ivermectin (see brands above): dose the size of an uncooked grain of rice for a rat weighing 1 lb or greater. Dose the size of a 1/2 grain of cooked rice for a rat weighing less than 1 lb. Give PO (orally), once weekly for three weeks . 4
Ivermectin 200 mcg/kg to 400 mcg/kg (0.2 mg/kg to 0.4 mg/kg), PO, SQ, repeat in 8-10 days 2. May be applied as a topical behind the ear.
Ivermectin 0.2 mg/kg q7 days x 3 weeks; PO, SQ, 1. May be applied as a topical behind the ear.
The following dosing instruction contributed by C.Himsel-Daly DVM.
When having to dilute ivermectin: Dilute the 1% solution (which is the injectable used for cattle) with propylene glycol 1:10. Take 1 mL ivermectin and mix with 9mL PG; thus diluting it from a 10 mg/mL solution to a 1 mg/mL solution, and dose at 200-400 mcg/kg (0.2 mg/kg-0.4 mg/kg). This makes it more accurate for the really wee ones.
*Note: in the event propylene glycol is not a diluting medium desired for topical application of the injectable form of ivermectin, mineral oil may be used as an alternative diluting medium.
Ivermectin Oral Sheep Drench: Ausmectin Sheep Drench:0.8g/L = 0.8mg/mL solution (Australia)
Dosing as follows:
0.125 mL once weekly for 3 weeks for rat weighing 500 grams. 23
*Note: for rats of a different weight: divide the weight of the rat by 500 grams and multiply that answer by 0.125 for the correct dose.
Topical (Spot on) behind the ear or back of neck
0.25 mL once weekly for 3 weeks for rat weighing 500 grams. , 23
*Note: for rats of a different weight: divide the weight of the rat by 500 grams and multiply that answer by 0.25 for the correct dose.
When using ivermectin horsewormer paste there is no need to decant paste if in the original tube. Decanting any fluid would concentrate the drug and thus raise the concentration in a volumetric dose, thus potentiating toxicity.
If in opening the original tube of paste it is found to have a drip of fluid at the end of the tube, before the actual paste emerges, all that is required is to express the tube, discard that bit of paste until uniform in consistency, and dose according to the veterinarian’s recommendation. If the paste has been dispensed in another container, then mix thoroughly before dosing. Paste tends to be a less accurate dosing method than using the parenteral, or topical product.
Fortunately the paste has a wide margin of safety.
Posted on June 23, 2003, 15:55,
Last updated on May 26, 2014, 19:04