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Thiabendazole

Anti-Infectives
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Brands

Veterinary approved use: Equizole and Omnizole
Human approved use: Mintezol

Availability

Comes in oral suspension, oral paste, and tablets.

Pharmacology

In the class of anthelmintics, thiabendazole is a benzimidazole compound. This drug is well absorbed and distributed through body tissues. It is rapidly metabolized in the liver within 48 hours of giving a dose.

The majority of this drug’s metabolites are excreted in urine with a small percentage being excreted in feces. The drug is completely eliminated from the body after 5 days.

Indications

Used to treat mixed helminthic infections, Oxyuric spp. , Hymenolepis, Trichinosis.

Drug Interactions or Contraindications

May be used with other drugs in mixed infections. Can increase Xanthine levels, such as theophylline, use with caution.

Not recommended to be used during pregnancy or in lactating females.

Use with caution in liver or kidney impairment.

Adverse Reactions

This drug is considered to have a wide margin of safety.

CNS:  lethargy possible in high doses

GI:   diarrhea, anorexia, possible in high doses

Dosage Recommendations

200 mg/kg, PO, SID times 5 days  9

Considerations

  • Giving fruit juice along with the drug will aid in the expulsion of worms as it helps by removing mucous that intestinal worms attach too.
  • Keep in closed container in a dry place.

Posted on June 23, 2003, 15:59, Last updated on May 24, 2013, 11:11 | Anti-Infectives



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