Thiabendazole

(also known as TBZ)

Brands

Mintezol

Availability

  • Tablets: 500 mg
  • Suspension: 100 mg/mL

Pharmacology

In the class of anthelmintics, thiabendazole is a benzimidazole compound. Thiabendazole is indicated for use in infections caused by susceptible parasites, fungi and bacteria.

The drug is well absorbed and distributed through body tissues with peak levels occurring in about 2 to 7 hours. 27

It is rapidly metabolized in the liver. The majority of this drug’s metabolites are excreted in urine with a small percentage being excreted in feces within about 48 hours of dose being given. The drug is completely eliminated from the body after 5 days. 27

Safety not confirmed in pregnant and lactating rats.

Indications

Used to treat mixed helminthic infections (e.g., roundworms, pinworms, tapeworms, threadworms).

Drug Interactions or Contraindications

  • May be used with other drugs in mixed infections. Can increase Xanthine levels, such as theophylline, use with caution.
  • Not recommended to be used during pregnancy or in lactating females.
  • Use with caution in liver or kidney impairment.

Adverse Reactions

This drug is considered to have a wide margin of safety.

CNS: lethargy possible in high doses

GI:  diarrhea, anorexia, possible in high doses

Dosage Recommendations

50 mg/kg to 100 mg/kg, PO, q24hr for 5 days  34, 35, 41

or

100 mg/kg, PO, for 5 days  27

or

200 mg/kg, PO, SID times 5 days  9

Considerations

  • Giving a juicy type of fruit along with the drug will aid in the expulsion of worms as it helps by removing mucous that intestinal worms attach too.
  • Keep in closed container in a dry place.

Cross-references

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