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Brand

Tylan, Elanco

Availability

Comes in oral powder and injectable.

Pharmacology

Tylosin is a macrolide, bacteriostatic antibiotic. It is similar in structure, mechanism of action, and spectrum as that of Erythromycin.

Although well distributed systemically, after absorption, it does not penetrate cerebral spinal fluid well.

It is concentrated in the liver and excreted unchanged in the urine and bile.

Indications

Used in treating mild to moderately severe forms of respiratory tract, skin, and soft tissue infections caused by group A beta-hemolytic streptococci and mycoplasma pneumoniae.

Also used in the treatment of colitis.

Drug Interactions or Contraindications

May be antagonistic with Chloramphenical or Lincosamides, not recommended to use together unless benefits out weigh risks.

Tylosin when used with digitalis may increase digitalis glycoside blood levels, that could result in toxicity.

Adverse Reactions

GI:  diarrhea

Hepatic:  hepatotoxicity

Skin:  itching

Local: pain and swelling at injection site

Other:  overgrowth of non-susceptible bacteria or fungi

Dosage Recommendations

4.5 mg/lb , PO, SQ, IM , BID (as recommended on RMCA Drug Chart)  ⁴

or

10 mg/kg , PO , SQ, IM, q24hrs   ^1 2

or

Tylan injectable 4.5 mg/lb BID (can be mixed in liquid or food and given PO) ³

or

Tylan Soluble 1/8 to 1/4 tsp. in 1 c. drinking water mixed fresh every 3 days ³
or
1/64 tsp. in food BID ³

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Safe for use in pregnant does and rats under 4 months. See Raisin’ Rats Rattery, http://www.raisinrats.com/medicalinfo.html; M.Ruud, Breeder, RMCA Member

Considerations

If mixing in water change every three days and remove moist foods from diet to encourage drinking.

Posted on June 23, 2003, 14:27, Last updated on March 17, 2008, 16:49 | Antimicrobial Agents