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Brands

Fortekor (UK, Canada), Lotensin (US)

Availability

Scored Tablets: 5 mg and 20 mg

(*Note: the 5 mg scored tablets can be easily divided to make two 2.5 mg tabs for giving to rats at their appropriate dosing (see dosage below )

Pharmacology

Benazepril hydrochloride is a second generation ACE (angiotensin-converting enzyme) inhibitor.
As an ACE inhibitor it has the ability to block an enzyme that enables the production of a substance which causes blood vessels to constrict. As a result, benazepril hydrochloride reduces vasoconstriction, decreases peripheral and pulmonary vascular resistance and right atrial pressure in the heart. This helps to lower blood pressure, as well as, increase the supply of blood and oxygen to the heart.

Benazepril hydrochloride is distributed in the body more quickly than first generation ACE inhibitors. It does cross the placental barrier, but has not been shown to cause birth defects in animals when given in doses more than 3 times the highest recommended human dose. (http://www.pdqrx.com/lotensin.htm )

Benazepril hydrochloride is metabolized in the liver to the active substance Benazeprilat. The drug is equally excreted by both liver and kidney (unlike older ACE inhibitors) reducing the need for dose modification, or monitoring of kidney function in the presence of renal disease. The drug is excreted in breast milk, and excreted unmetabolized in feces.

Indications

Used for treatment of heart failure (CHF), and dilated cardiomyopthy. May be a consideration for use, with caution, in PGN (progressive glomerulonephroses) when hypertension is thought to be a factor.

Drug Interactions or Contraindications

When used with diuretics and other vasodilators, may cause hypotension. Monitor doses carefully.

Use of NSAIDs with benazepril hydrochloride may reduce its efficacy.

Adverse Reactions

CV:  hypotension; disturbances in heart rhythm

CNS:  sleep disturbances, or lethargy

GI: diarrhea

Blood:  neutropenia, agranulocytosis

Skin:  pruritus (itching)

Dosage Recommendations

0.5mg/lb, or 1 mg/kg , PO , once or twice a day. The tablets are 2.5 mg, so a 1lb rat would be given 1/5th of a tablet. Starting at once a day, and increasing to twice a day as & when necessary (as the heart disease progresses). . ¹²

(*Note: due to its dual excretion in liver and kidney this drug may be safer to use in older rats , or those rats with progressive glomerulonephropathy, than first generation ACE inhibitors. )

Considerations

May be used in combined treatment with diuretics (lasix) , digoxin, or antiarrhythmics as deemed appropriate by a veterinarian.

Monitor weight. Report weight gain or increased edema (swelling).

Avoid high sodium, high potassium foods

Store in cool dry area and away from direct light.

Posted on February 16, 2005, 16:21, Last updated on October 5, 2008, 17:50 | Cardiovascular Drugs