Back to NSAIDs
It is absorbed rapidly and excreted in the urine.
Not recommended where active gastrointestinal bleeding is present.
Since many NSAIDs have the potential to produce gastrointestinal ulceration and bleeding avoid concomitant use of ibuprofen with aspirin, phenylbutazone, corticosteroids or other NSAIDs.
Due to fluid retention properties of NSAIDs (nonsteroidal anti-inflammatory drugs), the effect of diuretics may be reduced, and increased dosage of diuretics may be needed. Care should be taken if a rat has been placed on Lasix, or hydrochlorothiazide.
Selective and nonselective NSAIDs should be avoided or used with caution in rats having a history of chronic renal disease, congestive heart failure, or liver disease in order to prevent acute kidney failure. Studies indicate increased incidence of adverse effects with increasing dosages of selective and nonselective NSAIDs. Some medications, such as ACE inhibitors, and beta blockers, may increase NSAID-related renal complications.
GI: diarrhea, constipation, gastric distress
Skin: itching, fluid retention
Posted on June 23, 2003, 16:24,
Last updated on December 7, 2016, 19:59