Nuprin, PediaProfen, Children’s Advil, Motrin
- Tablets and liquid form and can be purchased over the counter.
A synthetic nonsteroidal drug that is analgesic, anti-inflammatory, and antipyretic. Like other NSAIDs the therapeutic action of ibuprofen is thought to be the inhibition of prostaglandin synthesis (Cox I & II).
It is absorbed rapidly and excreted in the urine.
Used to reduce pain and tenderness as well as minor swelling.
Drug Interactions or Contraindications
- Although there are no reported interactions when using acetaminophen and ibuprofen concurrently, it is not recommended to do so.
- Not recommended where active gastrointestinal bleeding is present.
- Since many NSAIDs have the potential to produce gastrointestinal ulceration and bleeding avoid concomitant use of ibuprofen with aspirin, phenylbutazone, corticosteroids or other NSAIDs.
- Due to fluid retention properties of NSAIDs (nonsteroidal anti-inflammatory drugs), the effect of diuretics may be reduced, and increased dosage of diuretics may be needed. Care should be taken if a rat has been placed on Lasix, or hydrochlorothiazide.
CV: edema (swelling)
GI: diarrhea, constipation, gastric distress
Skin: itching, fluid retention
10 mg/kg to 30 mg/kg, PO, q4hr 1, 28, 34
15 mg/lb to 60 mg/lb, PO, q4hr (low dose for analgesia, high dose for anti-inflammatory effect) 20
- Give with food to avoid GI reactions.
- Care should be taken if giving to a rat where liver and/or renal impairment is thought to be present.
- Ibuprofen (like other medications of similar characteristics) should be discontinued prior to any type of surgery, in rats, due to mild interference with clotting.
- Store tablets and liquid at room temperature in a dry place.