Tobramycin Ophthalmic




  • Ophthalmic solution: 0.3%
  • Ophthalmic ointment: 0.3%


Tobramycin, an aminoglycoside, is a bactericidal agent that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.

Its spectrum of activity includes aerobic Gram-negative organisms and some aerobic Gram-positive organisms.

Tobramycin ophthalmic is an FDA pregnancy category B drug, and thought to be safe for use during pregnancy. However, it is unknown whether tobramycin ophthalmic is passed in breast milk. Check with veterinarian prior to use in pregnant or lactating rats.


Used for the treatment of external eye infection where Gram-negative bacteria are thought to be the cause.

Drug Interactions or Contraindications

  • Not recommended for long-term use due to possible overgrowth of non-susceptible organisms.
  • Do not use where corneal abrasion is present, or in infections where viral or fungal organisms are believed to be the cause.

Adverse Reactions

CNS: temperature elevation

EENT: blurred vision, burning or stinging on instillation, lid itching or swelling, conjunctival redness

Other: overgrowth of non-susceptible organisms

Dosage Recommendations

Apply one drop to affected eye 4 to 5 times per day, or as directed by the veterinarian. 12 Used successfully by:  Richard Mckinniss, DVM


  • Pet owners should be sure to wash hands before and after applying drops or ointment to a rat’s eye(s). Wipe excessive lacrimation (porphyrin around the eyes in rats) or debris from eye(s) before application. Do not touch dropper or tube opening to any surface, including eyes or hands. The dropper or tube opening is sterile, and if contaminated it could cause additional infection in the eye.
  • Do not use any eyedrop that is discolored or has particles in it. Check expiration date.
  • Discontinue use if the following occurs: keratitis, redness, increased lacrimation, swelling of eye, or if rat starts to scratch eye in attempt to relieve itching.
  • Store tobramycin ophthalmic at room temperature away from moisture and heat. Keep the bottle or tube properly capped.
  • Richard Mckinniss, DVM, Fern Park, Florida


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